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The most effective way that I have found to click a mouse button quickly requires you to rest the rear of your palm on the back of your mouse and then LIGHTLY rest 2-3 fingers across the front edge of the mouse button. Vibrate those fingers downward, this is somewhat stressful but you can probably break 200 clicks/minute if you manage to do it properly. Your arm may give out before a minute is up, though... this might double as an exercise for forearm muscles!

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