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If you mean setting the starting lives higher in the options then: no The drawback it creates, however, is cutting down your end-stage score. Starting with 4 lives divides it by 2 (Extra life multiplier *0,5), and starting with 5 divides it by 5 (multiplier *0.2), usually. It may be a problem if you're aiming on scoring for the extra lives they give.

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